Powered by OpenAIRE graph
Found an issue? Give us feedback
ZENODOarrow_drop_down
ZENODO
Preprint . 2026
License: CC BY
Data sources: Datacite
ZENODO
Preprint . 2026
License: CC BY
Data sources: Datacite
versions View all 2 versions
addClaim

SYSTEMIC SCLEROSIS IN THE UNIVERSAL RESONANCE MODEL Epidemiology, Phase Structure, Fibrosis, and Reset

Authors: Domargård, Anita;

SYSTEMIC SCLEROSIS IN THE UNIVERSAL RESONANCE MODEL Epidemiology, Phase Structure, Fibrosis, and Reset

Abstract

This paper applies the Universal Resonance Model (URM) to systemic sclerosis, interpreting the disease as a progressive transition into a deep pathological attractor maintained by immune, vascular, and fibrotic feedback loops. Using epidemiological data, clinical phase structure, fibrosis dynamics, and the concept of reset windows, the paper frames systemic sclerosis as a disease of declining plasticity, increasing structural memory, and growing resistance to therapeutic perturbation, with decisive importance of timing and early intervention. This paper is part of the Universal Resonance Model (URM) series, which develops a systems-dynamic framework for understanding disease as transitions between dynamic regimes characterized by resilience, feedback structure, and attractor stability.

Keywords

timing of therapy, FOS: Clinical medicine, fibrosis, Immunology, attractor states, reset window, Universal Resonance Model, Medical and Health Sciences, Fibrosis Research, Rheumatology, feedback loops, Vascular Biology, Systemic sclerosis, scleroderma, Systems Medicine, disease dynamics, resilience

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Upload OA version
Are you the author of this publication? Upload your Open Access version to Zenodo!
It’s fast and easy, just two clicks!