Nipah virus (NiV) represents one of the most lethal zoonotic pathogens known to date, with recurrent outbreaks characterized by high case fatality rates, neurological involvement, and cross-species transmission affecting both humans and animals. Existing control strategies rely predominantly on reactive outbreak containment, exposure avoidance, and pathogen-centric biomedical responses, which have demonstrated limited scalability and preparedness value in high-risk regions. This preprint proposes a preventive, inverse-entity–guided conceptual framework that reframes Nipah virus risk not solely as a problem of viral exposure, but as a function of host susceptibility, systemic dysregulation, and outcome amplification. Without disclosing formulation, preparation, or application protocols, the paper outlines a directional pathway toward reducing severe disease probability through non-biological, non-exposure-based host conditioning strategies. The work is presented as a preprint for translational discussion, institutional collaboration, and protected intellectual property engagement, rather than as a therapeutic claim or clinical protocol. All actionable technical details remain undisclosed and subject to formal non-disclosure agreements.