Powered by OpenAIRE graph
Found an issue? Give us feedback
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
ZENODO
Preprint . 2026
License: CC BY
Data sources: ZENODO
https://doi.org/10.2139/ssrn.6...
Article . 2026 . Peer-reviewed
Data sources: Crossref
ZENODO
Preprint . 2026
License: CC BY
Data sources: Datacite
ZENODO
Preprint . 2026
License: CC BY
Data sources: Datacite
versions View all 3 versions
addClaim

Evidence-First Design for Consumer Health Formulations

Authors: Modali, Apoorva;

Evidence-First Design for Consumer Health Formulations

Abstract

Formulation-based consumer health products, such as dietary supplements, functional foods, drink mixes, and topical personal-care formulations, are widely used, repeatedly consumed, and often trusted by consumers to deliver specific functional outcomes. In the safety-sensitive context of formulation decisions, informal and externally driven heuristics, such as trending ingredients, supplier stock formulations, or formulator intuition, often guide the process rather than a structured, evidence-constrained design approach. This article presents an evidence-first design perspective for formulation-based consumer health systems and introduces the Evidence-First Functional Formulation Design (EFFFD) framework, which reorders formulation decisions around explicit problem definition, functional intent specification, hypothesis-level reasoning about how formulation components are expected to contribute to the stated functional intent, and evidence-constrained design. Artificial intelligence supports evidence discovery, dosage-range aggregation, interaction analysis, and safety risk screening, with expert review limited to a final pre-production feasibility and safety check. By formalizing upstream design logic and separating functional intent from market-driven heuristics, EFFFD increases the likelihood of functional effectiveness while improving transparency, reproducibility, and scientific defensibility in safety-sensitive formulation design.

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green