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Preprint . 2026
License: CC BY
Data sources: Datacite
ZENODO
Preprint . 2026
License: CC BY
Data sources: Datacite
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Genomic Architecture of Giftedness and Neurodivergence: An Analysis of Epistasis and Compensatory Mechanisms within the Genetic Intelligence Project (GIP)

Arquitetura Genômica da Superdotação e Neurodivergência: Uma Análise de Epistasia e Mecanismos Compensatórios no Âmbito do Genetic Intelligence Project (GIP)
Authors: Abreu Agrela Rodrigues, Fabiano;

Genomic Architecture of Giftedness and Neurodivergence: An Analysis of Epistasis and Compensatory Mechanisms within the Genetic Intelligence Project (GIP)

Abstract

This study, part of the Genetic Intelligence Project (GIP), examines the genetic architecture of superior intelligence within a control group of 200 gifted individuals, from which 35 volunteers were selected for in-depth analysis. The selection of this subgroup was based on the reliability of phenotypic data, including documented life histories, clinical interviews, and consistent Wechsler Scale (WAIS-III) results, which mirror the data of the entire control group. The methodology employed whole-genome sequencing and imputation, processed through the PGS Catalog and Open GWAS. To ensure strict scientific validation based on international studies, GIP "sentinel gene" results were bypassed in this specific analysis. The findings reveal that profound giftedness and neurodivergent profiles operate through epistatic mechanisms, where "islands of excellence" in memory and executive function compensate for modest global performance bases. To ensure confidentiality and participant protection, names are not disclosed, and anonymized profiles are used as references for the technical examples provide..

Keywords

Neurodivergence, Wechsler Memory Scale/statistics & numerical data, Wechsler Scales/standards, Wechsler Scales, Wechsler Memory Scale, (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride, Genomics, Wechsler Memory Scale/history, Giftedness, Wechsler Memory Scale/standards, Wechsler Scales/history, Wechsler Scale

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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