Non-coding RNA (ncRNA) possesses various biological functions and play key regulatory roles in biological processes by interacting with other biomolecules, such as proteins, RNAs and the genome. These interactions have been implicated in almost all physiological and pathological conditions and involve processes such as cell growth and development, tumorigenesis and tumor invasion. With the development of high throughput sequencing and experimental technologies, extensive RNA–protein interaction (RPIs) information has been accumulated. Identifying reliable and recurrent lncRNA-protein interaction within large-scale sequencing data helps elucidate the molecular mechanisms by which lncRNA exert regulatory functions within cells and facilitates the discovery of potential diagnostic and prognostic biomarkers. However, as these interactions are distributed throughout various resources, an essential prerequisite for effectively applying these data requires that they are deposited together. We present HuRInterDB (Human RNA-Protein Interaction Database), a comprehensive, standardized, and user-friendly database designed to provide an integrated resource of lncRNA–protein interaction data from 577 high-though data (encompassing 2,196,985 lncRNA-protein interaction derived from 55,924 lncRNAs and 7,863 proteins) and to support enhanced functional research on lncRNA. More importantly, HuRInterDB providing an easy-to-use online tool analysis for search and visualize proteins interacting with lncRNA, providing deeper insights into lncRNA functions and critical target genes.