Handball goalkeepers are required to perform explosive, reactive, and highly coordinated movements under intense match pressure. Despite these unique demands, many inter-collegiate teams follow general conditioning routines rather than goalkeeper-specific training. This study examined the effect of an eight-week strength and conditioning (S&C) program on the performance of inter-collegiate handball goalkeepers aged 17 to 25 years. The intervention targeted lower-body power, core stability, agility, shoulder strength, and reactive movement patterns. Physical performance was assessed using vertical jump height, change-of-direction tests, core endurance holds, and shoulder strength measurements. Technical performance was evaluated through a standardized reaction-time save test, while psychological readiness was measured using a self-report scale. Results revealed significant improvements in explosive power, lateral movement speed, trunk stability, and reactive save accuracy. Participants also reported higher confidence and perceived readiness. Overall, the findings suggest that a structured S&C program can substantially enhance the performance of young collegiate handball goalkeepers and should be integrated into regular training practices.