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ZENODO
Other literature type . 2026
Data sources: ZENODO
ZENODO
Other literature type . 2026
Data sources: Datacite
ZENODO
Other literature type . 2026
Data sources: Datacite
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Claim

Hypoxia as a Spatial Coordination Signal Rather Than a Metabolic Stress in Non-Seminomatous Germ Cell Tumors: A Systems-Level Perspective

descriptionPublicationkeyboard_double_arrow_right Other literature type 05 Jan 2026Publisher:Zenodo
Authors: Stefan, Ionut Alexandru;

doi: 10.5281/zenodo.18155340 , 10.5281/zenodo.18155339

Hypoxia as a Spatial Coordination Signal Rather Than a Metabolic Stress in Non-Seminomatous Germ Cell Tumors: A Systems-Level Perspective

Abstract

Traditional oncology views tumor hypoxia primarily as a metabolic stress that triggers survival responses through HIF1α activation. However, systems-level analysis of nonseminomatous germ cell tumors (NSGCT) reveals a fundamentally different role: hypoxiafunctions as an informational gradient that orchestrates spatial organization and phenotypic distribution within the tumor ecosystem.

Keywords

Hypoxia as a Spatial Coordination Signal, Hypoxia Testicular Cancer, Non-Seminomatous Germ Cell Tumors

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
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Average
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Related to Research communities
Cancer Research