Hypothyroidism is a common metabolic disorder characterized by reduced thyroid hormone production, leading to symptoms such as fatigue, weight gain, dry skin, hair loss and metabolic slowing. In Ayurveda, the condition can be understood through concepts of Agnimandya, Ama formation, Kapha–Vata vitiation and Srotorodha. This case study presents a 30-year-old female patient diagnosed with hypothyroidism, who was managed with an integrative Ayurvedic protocol comprising Anu Taila Nasya and Vyoshadi Guggulu for 6 weeks. Treatment focused on correcting Agnimandya, reducing Kapha accumulation, improving metabolism, and supporting thyroid function. Significant clinical improvement was observed, including reduction in fatigue, puffiness, weight gain and dryness of skin. Laboratory parameters improved markedly, with T3 increasing from 0.38 to 1.45 ng/dl, T4 from 3.81 to 7.63 µg/dl, and TSH decreasing from 12.11 to 4.21 µIU/ml. The results suggest that the combination of Anu Taila Nasya and Vyoshadi Guggulu may be effective in restoring metabolic balance and improving thyroid function. Further studies with larger sample sizes are recommended to validate these findings.