Agricultural activity significantly modifies the quality and dynamics of water in the environment. By transforming the plant cover, working the soil, and adding fertilizer and pesticides, agriculture alters the cycle of water and its compounds. The quality of water around the world has deteriorated significantly in recent years, due to uncontrolled industrial discharges, the intensive use of pesticides and chemical fertilizers in agriculture as well as the disorderly exploitation of water resources. These produce a chemical modification of the water and make it unsuitable for the desired uses. the European directive which sets, for water intended for consumption, at 0.1μg/l the maximum authorized concentration for each pesticide and at 0.5μg/l that concerning the total pesticides. To fight water pollution by agricultural pesticides origin, Western countries have developed numerical models of pesticide transfer, the use of which remains very difficult in sub-Saharan Africa due to the insufficiency of the necessary data and parameters, however Agriculture represents the main activity of more than 80% of the population in sub-Saharan Africa. In this work, a new model for the flow of pesticide-laden water was developed. This model was compared in terms of performance to the PRZM and PEARL models on horizons of 0-20 cm, 20-50 cm, 50-100 cm and for time intervals of 10 min, 20 min, 30 min, 40 min , 50 mins, 60 mins, 70 mins and 80 mins. The performance of the developed model was respectively 0.95; 0.94 and 0.93 on the horizons of 0-20, 20-50 and 50-100 cm. Those of the PRZM model were respectively 0.96; 0.97 and 0.94 over the same horizons and those of the PEARL model were respectively 0.98; 0.98 and 0.97 over the same horizons. To better compare the performances of these different models, the RMSE and MAPE values were calculated for each model and for each horizon. The MAPE(%) values for the developed model were -2.17, respectively; -1.66 and -3.88 for the 0-20, 20-50 and 50-100 cm horizons and those of RMSE were 4.13x10-5 respectively; 4.43x10-6 and 5.45x10-6. The MAPE(%) values for the PRZM model were -0.69, respectively; -0.49 and -2.81 for horizons 0-20, 20-50 and 50-100 cm and the RMSE values were 1.36x10-5, respectively; 1.96x10-6 and 3.54x10-6 for the same horizons. The MAPE(%) values for the PEARL model were -0.33, respectively; -0.28 and -2.68 for the 0-20, 20-50 and 50-100 cm horizons while those of RMSE were respectively 5.45x10-6; 3.54x10-6 and 1.47x10-6. The good performance of the developed model allows it to be used for simulating the transfer of water laden with pesticides in watersheds.