Abstract: Background: The sap from oil palm (Elaeis guineensis) notably called “palm wine” is a popular traditional alcoholic beverage commonly consumed in very large and chronic dimensions by the multitude for either cultural, personal or ceremonial reasons. It is known to have alcoholic contents upon fermentation. Aim: This study aimed at investigating the effect of sub-acute administration of fermented Elaeis guineensis sap (palm wine) on morphometric parameters such as total body weight and brain volume using adult wistar rats. Methodology: Unadulterated palm wine was authenticated as genuine Elaeis guineensis Sap, diluted with 50% clean tap water, and allowed to ferment at room temperature for 24 hours before being administered to the rats. Twenty five (25) healthy male wistar rats with average weight of 200g were divided into five groups (n=5). Group A served as the normal controls and received only rat chow and distilled water daily. Group B, C, D, and E were received increasing volumes of fermented palm wine via oral cannulas in progressions of 1ml, 2ml, 4ml, and 8ml respectively. The experimental procedure for this study lasted for 14 days. Total body weights of the experimental animals were noted on intervals (Day 1, 5, 10 and 15). 24 hours after their last administration (Day 15), the rats were sacrificed under ketamine (100mg/ml) as anesthesia. Their brain mass were carefully harvested whole and weighed via water displacement method to determine the total brain volume. Results: Higher doses relatively led to drastic reduction in total body weights and increased brain weights/volume of the experimental animals used relative to the control at the end of the experiment. Conclusion: The fermented sap from oil palm (Elaeis guineensis) clearly demonstrated a dose dependant undesirable effect on the morphometric parameters investigated. Keywords: Elaeis guineensis, Alcoholic beverage, Morphometric parameters. Title: EFFECTS OF SUB-ACUTE ADMINISTRATION OF FERMENTED ELAEIS GUINEENSIS SAP (PALM WINE) ON THE BRAIN VOLUMES AND TOTAL BODY WEIGHTS OF ADULT WISTAR RATS Author: Christian Chiemeka Ozor, Chike Ikechukwu Patrick Anibeze, Godson Emeka Anyanwu International Journal of Novel Research in Humanity and Social Sciences ISSN 2394-9694 Vol. 12, Issue 6, November 2025 - December 2025 Page No: 17-23 Novelty Journals Website: www.noveltyjournals.com Published Date: 31-December-2025 DOI: https://doi.org/10.5281/zenodo.18110542 Paper Download Link (Source) https://www.noveltyjournals.com/upload/paper/EFFECTS%20OF%20SUB-ACUTE%20ADMINISTRATION-31122025-10.pdf