
Single-cell technologies have recently enabled the discovery of many novel cell phenotypes. However, the complex assortment of cell phenotypes described in these studies remains fragmented across the scientific literature. The repository described here contains the CellLink corpus—a set of excerpts from recent human and mouse biomedical articles. The corpus was manually annotated by expert curators according to the annotation guidelines provided, to support the development and evaluation of machine learning models for automatically identifying cell types in the literature, including novel cell types. The excerpts (“passages”) included were selected from both abstracts and full-text articles published in 2019-2024 which focus on single-cell technologies or cell types. The corpus contains 22,360 annotations across 3,005 passages extracted from 2,765 articles in 467 journals. The corpus distinguishes 3 types of mentions: 83% of the annotations are cell phenotypes, 7% are heterogeneous cell populations, and 10% are vague cell populations. Mentions of the first two types are linked to Cell Ontology (v2025-01-08) identifiers where possible. Linking is with respect to the meaning of the mention in context, with matches labeled as exact or related. The source articles for all excerpts from full-text articles are licensed under CC-BY or CC0; CellLink annotations are released into the public domain. The repository contains the selected passages and manual annotations for the training and validation sets, provided in BioC XML format. The repository also contains the unannotated articles for the held-out test set; the annotations will be available (indirectly) to the public via CodaBench, to support fair evaluation. Users can upload predictions for the test set and receive an evaluation, as described on CodaBench. The evaluation script is included in this repository. A manuscript describing the corpus is in preparation. This record will be updated as the additional releases become public. Acknowledgment:This research was supported by the Intramural Research Program of the National Institutes of Health (NIH). The contributions of the NIH authors are considered Works of the United States Government. The findings and conclusions presented in this paper are those of the authors and do not necessarily reflect the views of the NIH or the U.S. Department of Health and Human Services. Example code minisnippet: """Print the first annotation in the CellLink train set.""" import bioc filepath = "train.xml" # edit here # load the bioc-xml filewith open(filepath, 'r', encoding='utf-8') as readfp: bioc_collection = bioc.load(readfp) first_document = bioc_collection.documents[0]first_passage = first_document.passages[0]first_annotation = first_passage.annotations[0]print(first_annotation) >> BioCAnnotation[id=0,text='progenitor cells',infons=[type=cell_phenotype,identifier=(skos:exact)CL:0011026],locations=[BioCLocation[offset=317,length=16]],] Additional example programs are provided.
| selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 1 | |
| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Average | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Average | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Average |
