The scope of this deliverable is to describe in detail the Data Management Plan (DMP). The DMP specifies how project outputs will be handled during and after the ThrombUS+ project. It identifies information about what datasets the ThrombUS+ consortium is aiming to acquire/generate and preserve, in which format andthe data management lifecycle. Best practices in terms of metadata and archiving are described, ensuring that the datasets acquired or generated will be findable, accessible, interoperable, and reusable (FAIR), in accordance with the Horizon Europe (HE) Open Science (OS). As the DMP is a living document, this document constitutes the updated version of the initial DMP plan delivered in April 2024. The document covers changes with respect to the data collected by Clinical Study B2, as well as the management plan for the data collected via the additional Clinical Studies B3 and B4, which were not planned in the Grant Agreement. Respective updates will be published in Argos/Zenodo during the project.