
Convulsions, or seizures, are defined as sudden, involuntary, and violent muscle contractions resulting from various underlying conditions, most notably seizures themselves, but also including high fevers, head injuries, infections, and exposure to certain toxins. Although convulsions and seizures are often conflated, they are not interchangeable; seizures pertain to abnormal electrical activity in the brain and can present in several forms, including absence seizures, which are characterized by a brief lapse in awareness without muscle contractions. A convulsion is marked by uncontrollable muscle contractions and spasms, leading to abrupt and jerky movements, and may affect specific body areas or the entire body, with durations ranging from seconds to minutes. Tonic-clonic seizures are primarily responsible for convulsions, while numerous seizure types do not result in this physical manifestation, further underscoring the distinction. It is crucial to implement early, evidence-based treatment strategies to prevent mortality and complications associated with prolonged status epilepticus (SE). Benzodiazepines are recognized as the most effective first-line therapy for SE, though they are frequently under-dosed. Alternatives for second-line treatment include levetiracetam, fosphenytoin, or valproic acid, all demonstrating equivalent efficacy in managing established SE. In scenarios where patients develop refractory or super-refractory SE, inducing an anaesthetic coma may be necessary, although there exists a lack of high-quality evidence to guide the selection of anaesthetic agents, the depth and duration of the coma, EEG treatment targets, and strategies for weaning off anaesthesia. Recent investigations suggest that ketamine may effectively terminate status epilepticus, although definitive proof from prospective comparative studies remains absent. Understanding the aetiology of SE is essential as it is a significant predictor of patient outcomes and should inform therapeutic approaches. If an immunological etiology is suspected, prompt empiric treatment with immunomodulatory drugs is recommended.
Akanksha Borade*, Dr. K. R. Biyani, Dr. R. A. Ingle, Dr. P. N. Folane
Akanksha Borade*, Dr. K. R. Biyani, Dr. R. A. Ingle, Dr. P. N. Folane
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