Abstract Background: Titanium dental implants have become the standard for tooth replacement due to their mechanical strength, corrosion resistance, and excellent biocompatibility. Despite these advantages, implant insertion procedures may lead to the release of titanium particles due to friction and wear at the bone–implant interface, potentially causing peri-implant tissue inflammation. Aims: This study aimed to compare and evaluate titanium exfoliation from dental implants with different surface modifications during simulated surgical insertion procedures. Settings and Design: An in-vitro experimental study conducted using polyurethane foam blocks simulating human cancellous bone density. Methods and Material: Sixteen commercially available dental implants were categorized into four groups (n=4 per group) according to their surface characteristics: Group 1 – Sandblasted large-grit acid-etched (SLA) implants, Group 2 – Sandblasted with alumina acid-etched implants, Group 3 – Anodized surface implants, and Group 4 – Hydroxyapatite (HA)-coated implants. Each implant was inserted into polyurethane foam blocks with a density of 40 PCF following a standardized surgical drilling and insertion protocol. Optical Microscopy, Field Emission Scanning Electron Microscopy (FE-SEM), Energy Dispersive X-ray Spectroscopy (EDS), and Powdered X-Ray Diffraction (XRD) analyses were employed to detect and quantify titanium exfoliation. Statistical Analysis: Intergroup comparisons were performed using one-way ANOVA followed by post-hoc Bonferroni tests with significance set at p<0.05. Results: Titanium particle release was observed in all groups, with Group 1 and Group 2 exhibiting significantly higher titanium mass percentages and particle sizes than Group 3 and Group 4. Anodized surface implants demonstrated the least titanium exfoliation. Conclusions: Implant surface roughness plays a crucial role in titanium particle release. Anodized surfaces showed minimal exfoliation, indicating their potential advantage in reducing peri-implant inflammatory risks.