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ZENODO
Article . 2025
License: CC BY
Data sources: ZENODO
ZENODO
Article . 2025
License: CC BY
Data sources: Datacite
ZENODO
Article . 2025
License: CC BY
Data sources: Datacite
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Joint Optimization of Bolus Dose and Delivery Timing Using Reinforcement Learning for Type-1 Diabetes

Authors: Ball Mukund Mani Tripathi, O. Sai Sindhu, K. Satya Uday, P. Mounika;

Joint Optimization of Bolus Dose and Delivery Timing Using Reinforcement Learning for Type-1 Diabetes

Abstract

Keeping blood glucose levels within the safe range is a persistent issue in Type-1 Diabetes (T1D) management that is especiallyprominent during periods of mealtime rapid glucose variability. Traditional insulin management approaches, including Proportional–Integral–Derivative (PID) and heuristic Bolus-Based (BB) algorithms, rely on rules that are more or less manually tunedand using fixed pre-meal dosing times. These rules often lead to suboptimal glucose control, resulting in either hyperglycemiadue to delay onset of action in injected insulin, or hypoglycemia from overdose. We present a meal-timed reinforcement learning(RL) algorithmic framework that jointly optimizes insulin bolus dose and timing for glucose control. Using a Soft Actor-Critic (SAC) agent, the control system learns adaptive dosing algorithms based on continuous glucose feedback, meal intake, andphysiologic variability. The role of RL was evaluated by training in three separate virtual patient groups—the adult, adolescent, and child patient groups—each of which represented 30 virtual patients per cohort for 10 days of simulation—totalingin 900 virtual patient days of evaluation. Results from the RL control system found enhanced glucose control compared toconventional PID and BB controls, maintaining average Time-in-Range (TIR) of approximately 80% while also reducing TimeBelow-Range (TBR), and reduction in excess insulin utilization. Overall, these results exemplify that when dose and timingare jointly optimized with adaptive RL-based approaches, glucose control is accomplished more safely and physiologically thanwith commonly accepted static rules.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green