This paper presents a philosophical framework rooted in Eastern wisdom and oriented toward contemporary scientific dilemmas—the Great Dao Fully Deterministic Theory (GDF). GDF posits that the ultimate reality of the cosmos is the Great Dao, conceived as a non-local holographic information field whose initial complete state uniquely determines the entire trajectory of cosmic history, including physical evolution, biological processes, and conscious activity. The central tenet of GDF can be succinctly stated as: “Everything is predetermined, and so are thoughts.” While the ancient saying goes, “Every sip and bite is predestined,” GDF extends this to its logical extreme: “Every thought, every notion, is fully determined.” A representative maxim further clarifies its distinction from fatalism: “Your fate is fully fixed—your restless thoughts are part of it!” This underscores that mental activity is not futile resistance but an intrinsic unfolding of destiny itself.