Abstract: Adolescence is a critical transitional phase marked by profound physical, psychological, and social changes. Gynecological problems during this period are common yet frequently underrecognized, underreported, and inadequately managed due to stigma, lack of awareness, and limited access to adolescent-friendly health services. Conditions such as menstrual disorders, dysmenorrhea, polycystic ovarian syndrome, infections, pubertal disorders, and psychosocial concerns significantly impact adolescents’ quality of life, academic performance, and emotional well-being. Nurses play a pivotal role in early identification, holistic care, health education, counseling, and advocacy for adolescents with gynecological problems. This review article explores common gynecological issues affecting adolescents, examines their physical and psychosocial implications, and highlights evidence-based nursing interventions. Emphasis is placed on adolescent-centered care, confidentiality, cultural sensitivity, health promotion, and preventive strategies. Strengthening nursing competencies in adolescent gynecological care is essential for improving reproductive health outcomes and fostering lifelong healthy behaviors.