Abstract: Neurodevelopmental disorders (NDDs) represent a group of conditions characterized by impairments in cognitive, motor, communication, social, and adaptive functioning that emerge during early childhood and persist across the lifespan. The increasing global prevalence of conditions such as autism spectrum disorder, attention-deficit/hyperactivity disorder, intellectual disability, communication disorders, and specific learning disorders has placed substantial demands on healthcare systems, families, and educational institutions. Nurses play a pivotal role in the early identification, comprehensive assessment, therapeutic management, family support, and long-term care of children with neurodevelopmental disorders. This review article aims to examine the scope, principles, and evidence-based nursing interventions involved in the care of children with neurodevelopmental disorders. Emphasis is placed on holistic, family-centered, and multidisciplinary nursing approaches that address physical, psychological, social, and developmental needs. The article also explores challenges faced by nurses, ethical considerations, and emerging trends in pediatric neurodevelopmental nursing practice. Strengthening nursing competencies and integrating evidence-based strategies are essential to improving functional outcomes, quality of life, and social inclusion for affected children and their families.