RESUMEN | La presencia creciente de microplásticos en ambientes marinos representa una amenaza para los organismos filtradores, como los bivalvos, los cuales muestran una capacidad limitada para escapar de la exposición a estos agentes, filtrando fácilmente las partículas de polímeros mediante su alimentación. En este estudio, se analizaron 160 mejillones provenientes de un banco natural y de un cultivo suspendido. Se evaluó su condición fisiológica a partir del índice de condición (IC3) y el rendimiento (R). Los microplásticos se separaron en las muestras para inspección visual usando un microscopio estereoscópico, cuantificando su abundancia y caracterizándolos físicamente. Los mejillones de cultivo mostraron mayores masas totales pero menor condición fisiológica (IC3 = 32,1; R = 4,43) en comparación con los organismos de vida libre (IC3 = 43,9; R = 1,24). 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