This guide walks you through everything you need to start, run, and grow a preprint review club — whether you’re converting an existing journal club or building one from scratch. It covers choosing preprints, organising meetings, training early-career researchers, writing structured reviews, and sharing them on platforms like PREreview or Hypothes.is. Designed for labs, departments, and research communities, the guide shows how preprint review clubs can boost critical-reading skills, strengthen collaborative science, and make peer review more open, constructive, and fun. Complete with templates, workflows, discussion prompts, and sample emails, this resource is your step-by-step companion for transforming traditional journal clubs into modern, impactful spaces for scholarly dialogue.