Background. The misuse and unhealthy consumption of drugs is a widespread practice among students worldwide, with developing countries like Nigeria facing even more significant challenges in this regard. Self-medication is a common but risky practice among students. Despite their knowledge of drug use, many students engage in self-medication, increasing the risk of adverse effects from non-prescribed drugs. Objectives: This study evaluated the prevalence, knowledge, attitude and practices related to self-medication among pharmacy students at Nnamdi Azikiwe University Agulu, Anambra State, Nigeria. Methodology: A descriptive cross-sectional study was conducted among undergraduate pharmacy students in the Faculty of Pharmaceutical Sciences, Agulu. Data were collected using a semi-structured, self-administered questionnaire. Collected data was analysed using the SPSS Version 25.0. The level of significance was set at a p-value <0.05. Results: The participants' prevalence of self-medication within the last three months was 90.3. Most (98.1%) of the students were aware of self-medication, with 81% demonstrating a strong understanding. Self-medication was practised by 41.6% of students, mainly for common ailments. Reasons cited included good knowledge of the disease, experience with a similar illness, prevention, the mildness of the illness, and time-saving. Conclusion: The study revealed a high prevalence of self-medication among pharmacy students. Most students practised self-medication for common ailments, citing confidence in their knowledge, prior experience, prevention and convenience as key reasons.