Mumiyo, a traditional herbo-mineral preparation widely used in various traditional medical systems, has long been attributed numerous therapeutic properties, including effects on renal function and electrolyte balance. Despite extensive historical and ethnomedical usage, systematic evaluations of its physiological actions remain limited. This study aimed to investigate the diuretic and natriuretic effects of several geographically distinct types of mumiyo in rats subjected to an acute salt load. Wistar rats were administered mumiyo preparations intragastrically (50 mg/kg, 1% solution) followed by a standardized sodium chloride load (0.45% NaCl, 3% of body weight). Urine volume and sodium excretion were measured one hour post-administration. While none of the tested mumiyo varieties significantly increased diuresis compared with controls, all demonstrated notable effects on sodium excretion. Alai, Indian, and Altai mumiyo produced statistically significant elevations in natriuresis, with the Alai and Indian samples eliciting the strongest responses. The consistent natriuretic response observed in Central Asian varieties may serve as a useful criterion for mumiyo identification and quality assessment. Further investigations are warranted to elucidate the underlying mechanisms and potential clinical implications of these effects.