The BioBoosters network offers a challenge-driven hackathon concept with proven business impact and international reach. The hackathon helps to drive business transition and address sectoral challenges by: Bridging business with academia and research. Connecting cross-sectoral and international experts. Unboxing out-of-the-box ideas. Initiating innovation partnerships. This handbook provides a step-by-step guide for organising a hackathon and planning the communicationtasks related to the hackathon. To give targeted advice, it is divided into an Organisers’ Guide and a Communicator’s Guide. The handbook can be used for Training and initiating a new hackathon organiser or organising team member. It offers step-by-step guidance on organising a hackathon, addressing common concerns and providing advice on risk management. In addition, it shares best practices for creating added value for participants and making the most of your time together. Explaining and visualising the process, as well as the organisers’ role and contribution, to supportresourcing. It details the hackathon process and the tasks involved for organisers at each step. A clear accountof the organiser’s contribution and role can be used for planning resourcing and outlining the responsibilities of co-organisers. Inspiration for developing impactful open innovation processes and events. It offers insights and lessons from an exceptionally extensive piloting programme carried out through international co-operation. Feel free to apply this know-how to the development of impactful open innovation processes that support industry transition and facilitate the initiation of innovation partnerships.