Objective: The present study was designed to evaluate the fasting lipid profile of ethanol leaves extract of Gmelina arborea. Materials and Methods: Crude extract of Gmelina arborea was prepared from the dried plant leaves and using ethanol as the extracting solvent. The extract was orally administered to albino rats at dose range of 250, 500 and 1000 mg/kg body weight for a period of 28 days. The effects on body weight and lipid profile were studied. Results: The administration of ethanol leaves extract of G. arborea at 250, 500, and 1000 mg/kg body weight showed a significant decrease in total cholesterol, triglyceride, very low density lipoprotein-cholesterol, low density lipoprotein-cholesterol, and a significant increase in high density lipoprotein-cholesterol in all the treatments compared with the control. There was also no significant weight gain or organ weight gain in all the treatments compared with the control. Conclusion: Ethanol leaves extract of G. arborea could be used in the management of hyperlipidemia and in weight management in experimental animals.