Riboswitches that are also called as microRNAs are small RNA that falls under category of non coding metaphorically sequences that are conserved which get produced in a number of tissues as well as cells which perform a major role that involves physiological and pathological outcomes of the body. There are some evidences provided by researchers for the implication of miRNAs in infectious diseases caused through bacteria by manipulating inflammatory responses, cell penetration, apoptosis and tissue proliferation. The review gives major discussion for the part of miRNAs in progression of infection and their impact on host immunity to improve the diagnosis, prevention and treatment strategies for the patient.