Azadirachta indica, commonly known as neem, is a well-known medicinal plant extensively used in traditional medicine systems like Ayurveda and Unani for its diverse therapeutic properties. Among its many applications, neem has gained significant attention for its effectiveness in treating various skin disorders due to its antibacterial, antifungal, anti-inflammatory, antioxidant, and wound-healing activities. "Neem has shown effectiveness in treating various dermatological issues such as acne, eczema, psoriasis, fungal skin infections, and ulcers." "Numerous laboratory and animal studies have confirmed the antimicrobial and wound-healing potential of neem" while topical formulations such as neem oil, creams, and extracts have shown clinical efficacy in dermatological applications. This review highlights the phytochemistry, mechanisms of action, therapeutic benefits, and safety profile of Azadirachta indica in managing skin diseases, emphasizing its potential as a natural alternative or adjunct in modern dermatological therapy.