This paper advances Synthesism as a philosophical framework providing coherence for the integration of diverse knowledge sources within the MKS®-Thronaxis metadisciplinary architecture. Building upon the Harmonized Terminological Prolegomenon (Maiywa-Masai, 2025), This study demonstrates that Synthesism operates through Four Movements—Reception, Observation, Integration, Application—which enables principled integration without reduction or collapse. The paper distinguishes Synthesism from Hierarchical Epistemology, which provides cognitive ordering through Four Epistemic Axes (Revelation → Inspiration → Reason → Sanctified Opinion). Through rigorous biblical exegesis of Romans 12:1–2 and integration of Fernando Canale’s cognitive hermeneutics, the study shows how the MKS The Thronaxis framework transcends the classical rationalism-fideism dichotomy. By establishing revelation as the ultimate epistemic Authority while affirming reason’s indispensable cognitive role in faith and discernment, the Four Pillars of MKS-Thronaxis— Thronaxis Cosmology (ontological grounding), Hierarchical Epistemology (cognitive ordering), Synthesism (philosophical coherence), and Empirical Metadisciplinary Theology (methodological integration)—together accomplish homecoming reintegration: the return of fragmented disciplines to their proper places within an ordered whole.