This paper undertakes a comprehensive reconstruction of the Hellenistic world-system, conceptualizing the 'Hellenistic Cosmopolis' as a primary instance of ancient globalization. Spanning from the conquests of Alexander the Great in the late 4th century BCE to the rise of Roman dominance, the Hellenistic period witnessed unprecedented levels of interconnectedness across vast geographical areas, encompassing the Mediterranean, the Near East, and parts of Asia. Drawing upon an interdisciplinary approach that integrates archaeological findings, numismatic evidence, papyrological studies, and classical textual sources, we analyze the intricate economic, cultural, and political networks that characterized this era. The study applies a modified world-systems theory framework to understand the core-periphery dynamics, trade routes, urbanization patterns, and cultural syncretism that shaped the Hellenistic oikoumene. We argue that the Hellenistic period constituted a distinct and coherent globalizing system, driven by factors such as the establishment of new cities, the widespread adoption of Koine Greek, the integration of diverse administrative practices, and the flow of goods, ideas, and people. The paper highlights the unique features of ancient globalization, differentiating it from modern phenomena while emphasizing its lasting impact on subsequent historical developments. Ultimately, this research aims to provide a nuanced understanding of the mechanisms and implications of large-scale interconnectedness in antiquity, positioning the Hellenistic Cosmopolis as a crucial case study for the study of global history.