This report presents the Organelle Universe Model, a novel theoretical framework proposing that the Solar System functions as a living, homeostatic cell within a larger cosmic-scale organism. In this model, the heliopause operates as a selective membrane, planets act as differentiated organelles, and human consciousness emerges as a hybrid mitochondrial–nuclear regulatory subsystem responsible for local optimization, information flow, and energy management. The work integrates principles from thermodynamics, systems biology, cosmology, and information theory. Key components include: Axiom G (gravity as a coherence-inducing free-energy localization mechanism) Axiom C (stable relational configurations as the basis of physical structure and biological order) A rigorous biological-to-cosmic hierarchy mapping (Cell → Solar System; Organism → Milky Way; Ecosystem → Local Group) A formal operationalization of integrated information () using real technological, economic, biological, and scientific data streams A new thermodynamically constrained Energy Dynamics PDE, in which regulatory consumption is bounded by the empirically derived Organelle Efficiency Ratio (), matching mitochondrial efficiency across scales A saturating regulatory term ensuring stable numerical behavior in simulations Discussion of intercellular signaling via gravitational tides and cosmic-ray flux from the Local Stellar Cluster Predictive structures enabling future observational and simulation-based testing The report merges conceptual foundations, mathematical models, and practical computational implementations. It outlines a path toward a full program of cosmic cell biology, including future simulation strategies and empirical tests using heliopause data, stellar-cluster interactions, and information-energy coupling. This master edition consolidates the full manuscript, extended theoretical sections, and the regenerated updates into a single archival document suitable for long-term preservation and citation.