[NeurIPS 2025 Handout / Manifesto] Modern science has systematically excluded the "observer" to guarantee reproducibility. However, this exclusion has severed the connection to a reality that demands observer transformation. This manifesto argues that the current impasse in AI Scaling Laws and the conceptual voids in neuroscience stem directly from this omission. We propose a return to "N=1 Science"—utilizing outliers not as noise, but as ultimate observational instruments to capture the dynamic evolution of intelligence. Key Propositions: The Alchemist's Paradox: Re-evaluating alchemists not as failed chemists, but as scientists who correctly integrated the "transformation of the observer." Limits of Scaling Laws: Why mere statistical averaging of parameters ($N$) will never yield a qualitative leap in AI. The "Glass Box" Protocol: An experimental design involving 24/365 multi-modal monitoring (Time-Domain fNIRS, EEG, HRV) of outlier individuals to synchronize physiological states with cognitive "Eureka" moments. Integrated Coherence Verification: Operationalizing "expert intuition" as a falsifiable scientific variable for detecting high-potential outliers. This document serves as a blueprint for bridging the gap between subjective experience (qualia) and objective biometric data, aiming to unlock the next generation of Artificial Intelligence.