ABSTRACT: Breast cancer is the most common malignancy among women globally.1 The patients with breast cancer adopts different coping styles during their treatment time. This study investigated the effectiveness of empowerment programme on coping of post-mastectomy patients undergoing chemotherapy. Methods: This study adopted a quantitative research approach with a quasi-experimental pretest post-test control group design. Sr. Callista Roy's Adaptation model was the theoretical support for the study.A purposive sampling technique with a total of 70 patients, 35 in each control and the experimental groups were selected for the study. The data were collected with socio-personal and clinical data sheets and the Jalowiec coping scale. On the first day of the test, a pre-test was conducted and an empowerment programme was given to the experimental group, which includes a structured teaching programme, mindfulness breathing exercises and mindfulness body scan meditation. The post-test was conducted at the end of the intervention. Results: The results reveals that the U value obtained for coping of post-mastectomy patients undergoing chemotherapy among the control and experimental group was 206.5 which was significant at 0.001 level. Conclusion: This indicates that among the post-mastectomy patients undergoing chemotherapy the empowerment programme was effective in improving the coping