Curcuma longa (turmeric) and Trigonella foenum-graecum (fenugreek) are herbs known for anti-inflammatory and wound-healing effects. To formulate and evaluate a topical polyherbal cream from turmeric and fenugreek extracts and test its anti-inflammatory activity. Hydroalcoholic extracts of both plants were prepared and added to different cream bases. The best formulation (F3) was selected after stability testing. Anti-inflammatory activity was studied in 20 rats using the formalin-induced paw edema model for six days. Betamethasone cream was used as the standard. The optimized cream was stable and non-greasy. It showed strong anti-inflammatory effects, similar to betamethasone. A polyherbal cream with turmeric and fenugreek is safe, stable, and effective for dermal inflammation.