The dissertation presents the interdisciplinary research of fundamental mechanisms that form the experience of “meaning” and support the everyday “existence” of living systems under conditions of possible awareness or unawareness of the emptiness of existence. The central category of the work is the constant subconscious (CSC), it is an autonomous biological program, the basis of any living organism for “existence”, a set of motivational modules, automatic scripts and regulatory devices: checkpoint (CP), reproductive inertia (RI), emergency self-destruction mechanism (ESDM), existential blockage (EB); which govern the being and ensure the viability of the organism regardless of the interpretations of consciousness. The CSC is also seen as an explicit working model that allows the formalization of the concepts of the axioms of pannihilism: correlations and memory (Σ, 𝑀) STM/MTM/LTM/SM/GM, thresholds of existence (θ, µ) and “amplitude of life” Ψ; from which the degree of metastable local asymmetry with respect to global nothingness is described. The philosophical 4 basis of the work is pannihilism, it is the radical ontological axiom: ∀𝑃 (𝐶𝑜𝑛𝑡𝑒𝑛𝑡(𝑃) → ¬𝑃(𝑁)), according to which the primary ontological “background” is absolute nothingness (global time), and local illusions (local time) are “temporal” asymmetries, possessing phenomenological status only if the thresholds of correlation and memory are met, thus the very emergence of the “big bang”, the universe where we all are now, on this basis the key concepts are introduced: “birth” as the first death (entry into the illusion of local time), “life” as the superposition Ψ𝑙𝑖𝑓𝑒 = α|𝑙𝑜𝑐𝑎𝑙⟩ + β|𝑛𝑢𝑙𝑙⟩ and its “end” as the “collapse” of the metastable configuration, the “return” to absolute nothingness. Methodologically, the work combines: causal constructions, logical-mathematical definitions, comparative-biological data (behavioral examples in birds, mammals, invertebrates), psychopathological analysis of mechanisms, and sociocultural analysis of various institutions as stabilizers of meaning. Special attention is paid to the phenomena of EB and CP, their role in preventing existential paralysis of consciousness (EPC) and possible realizations of ESDM. The dissertation demonstrates a logico-philosophical worldview that allows us to rethink the concepts of consciousness, subconsciousness, being and absolute nothingness, as well as responsibility and memory, and raises practical questions about the ethics of intervening in vitality support mechanisms.