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ZENODO
Article . 2025
License: CC BY
Data sources: ZENODO
ZENODO
Article . 2025
License: CC BY
Data sources: Datacite
Claim

ОИВ ИНФЕКЦИЯЛИ БЕМОРЛАРДА ВИРУСЛИ ЖИГАР КАСАЛЛИКЛАРИ

descriptionPublicationkeyboard_double_arrow_right Article 22 Nov 2025Publisher:Zenodo

doi: 10.5281/zenodo.17684436

ОИВ ИНФЕКЦИЯЛИ БЕМОРЛАРДА ВИРУСЛИ ЖИГАР КАСАЛЛИКЛАРИ

Abstract

Антиретровирус терапия (АРТ) жорий этилиши билан ОИТС билан боғлиқ касалликлардан ўлим сезиларли даражада камайди, аммо жигар касалликлари ОИВ билан касалланганлар орасида ОИТС бўлмаган ўлимнинг асосий сабабига айланди. АРТ даврида жигар патологиясининг спектри оппортунистик инфекциялар ва неоплазмалардан сурункали вирусли гепатитлар, дори воситаларининг гепатотокциклиги, спиртли ичимликларни суиистеъмол қилиш ва жигарнинг алкоголсиз ёғли касалликлари томон силжиди. ОИВ билан касалланган одамларда цирроз ривожланиш хавфи умумий популятсияга қараганда юқори. Асосий эътибор гепатит C (ВГС) ва Б (ВГВ) вируслари билан коинфекцияланган беморларга қаратилган, аммо ОИВнинг ўзи бошқа омилларнинг зарарли таъсирини синергик равишда кучайтирган ҳолда, стеатоз ва жигар фиброзига ҳисса қўшиши мумкинлиги исботланган. Фиброгенез механизмлари жигар юлдузсимон ҳужайраларининг фаоллашуви, ОИВ таъсирида оксидланиш стресси ва трансформатсияловчи ўсиш омили (ТГФ-β) ишлаб чиқарилишининг кучайишини ўз ичига олади.

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Average
Powered by OpenAIRE graph
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green