Numerous comorbidities, including cardiovascular disorders, depression, diabetes mellitus, dyslipidemia, osteoporosis, rhinosinusitis, and primarily gastro-oesophageal reflux disease and allergic rhinitis, are frequently linked to asthma. Despite the fact that bronchodilators are crucial for treating asthma, their overall effects on comorbid asthma, whether positive or negative, are not well described. This narrative review investigates how bronchodilators may affect asthmatic comorbidities.