Abstract: This case study presents the nursing care management of a 66-year-old woman diagnosed with symptomatic cholelithiasis and treated with laparoscopic cholecystectomy. The purpose of the study was to apply theoretical knowledge to clinical practice through comprehensive assessment, identification of nursing needs, implementation of evidence-based interventions, and evaluation of patient outcomes. Orem’s Self-Care Deficit Theory guided the nursing approach, utilizing both partly compensatory and supportive-educative systems. Key postoperative issues included acute pain, risk of fluid and nutritional imbalance, and lack of disease-related knowledge. Targeted interventions such as pain management, hydration monitoring, dietary education, ambulation support, and health teaching were implemented to promote recovery and enhance self-care ability. Diversional therapies and individualized patient support further contributed to psychological comfort and coping. The patient demonstrated steady improvement, maintained stable vital signs, and was discharged with appropriate instructions regarding diet, activity, medication adherence, and follow-up care. This case study strengthened the application of holistic nursing practice, clinical judgment, and patient-centered education in managing cholelithiasis. Keywords: nursing care management, symptomatic cholelithiasis, laparoscopic cholecystectomy. supportive-educative systems. Title: A Case Study On Cholelithiasis Author: Nofiah Dhabaan Alshammary International Journal of Novel Research in Healthcare and Nursing ISSN 2394-7330 Vol. 12, Issue 3, September 2025 - December 2025 Page No: 65-92 Novelty Journals Website: www.noveltyjournals.com Published Date: 19-November-2025 DOI: https://doi.org/10.5281/zenodo.17648635 Paper Download Link (Source) https://www.noveltyjournals.com/upload/paper/A%20Case%20study%20on%20cholelithiasis-19112025-1.pdf