This document outlines the acceptance criteria for a European-wide distributed genomics data infrastructure. The scope of these criteria is defined from the perspective of the EDIC as the coordinating body, focusing on the requirements necessary for a node, central as well as local, to participate in and contribute to a secure, interoperable, and cohesive distributed system. These criteria serve as the starting point for requirements that all participating national nodes and their respective local implementations must meet to ensure the integrity, security, and functionality of the overall infrastructure.