The End-to-End Proactive Security Connectivity Manager (ePEM) system is introduced as a cutting-edge connectivity manager designed to orchestrate and secure end-to-end services within the Holistic, Omnipresent, Resilient Services for future 6G wireless and computing Ecosystems (HORSE) security infrastructure for future Sixth-Generation (6G) networks. It plays a pivotal role in managing Network Function Virtualization (NFV) and applicative services, providing observability and data simplification to improve decision-making and security management. ePEM employs meta-actions for security contingency planning and maintains a comprehensive database of the network's logical topology. Built on a modular architecture, it supports various Network Function (xNF) and ecosystems, using blueprint profiles to standardise the operations for network elements.