ABSTRACTCubosomes are nanostructured, self-assembling liquid crystalline particles that resembleliposomes but have a distinct cubic phase structure with improved stability and flexibility. Due totheir capacity to effectively encapsulate and deliver a variety of nanoparticles, cubosomes, whichwere initially described by Larsson in 1980, have gained considerable attention innanotechnology-based drug delivery.Broad variety of chemicals, such as proteins, peptides,nucleic acids, and chemicals with low molecular weight.Cubosomes facilitate regulated andtargeted medication release because they have a bicontinuous cubic liquid crystalline phase withinternal aqueous channels. Their use has increased because of a variety of preparationtechniques, including top-down and bottom-up methodologies, as well as novel formulationtechniques like surface functionalization and stimulus-responsive systems. Despite difficultiessuch as excessive viscosity, stability, drug leakage, manufacturing expenses, and scalability,cubosomes have a bright future in the pharmaceutical, cosmetic, agricultural, and diagnosticindustries. Ongoing improvements are being made to delivery systems.