Purpose: To describe three cases of angioid streaks revealing pseudoxanthoma elasticum (PXE) and to discuss the diagnostic, clinical, and therapeutic aspects of this uncommon association. Methods: Observational study of three patients managed at the Ophthalmology Departments of the Specialty Hospital of Rabat and Hassan II Military Hospital of Laâyoune. Results: Three patients (two men and one woman, aged 58, 55, and 42 years) presented with progressive bilateral visual loss. Fundus examination revealed dark, radially oriented lines emerging from the optic disc, consistent with angioid streaks. Fluorescein angiography confirmed the diagnosis. Dermatologic evaluation revealed pseudoxanthoma elasticum, while cardiovascular and skeletal investigations were unremarkable. Conclusion: Angioid streaks represent a rare manifestation of Bruch’s membrane rupture, most frequently associated with PXE (Grönblad–Strandberg syndrome). Early detection of choroidal neovascularization and prompt anti-VEGF therapy are essential to preserve visual function.