This work, prepared by Mabrouk Brahimi & Marco, presents the Unified Thermal Photon Drift Framework (UTPDF), integrating the Multi-Medium Cosmos Theory (TMMC) and the Universal Model Framework (UMF) to describe photon behavior in vacuum under thermal gradients. TMMC conceptualizes vacuum as multi-layered with distinct informational and energetic densities, while UMF represents vacuum dynamics via prime modes as fundamental information states. By mapping TMMC layers to UMF prime modes, the UTPDF model demonstrates that thermal gradients induce reorganization of the vacuum’s informational structure, generating directional photon drift. Predictions include linear scaling of drift with temperature differences, enhancement with additional layers or modes, and dependence on cavity dimensions. The framework provides a unified conceptual understanding of vacuum as a structured informational medium and opens avenues for experimental validation of photon drift phenomena.