The present study aims to formulate and evaluate a skin hydration cream incorporating hyaluronic acid as a key active ingredient. Hyaluronic acid, a naturally occurring biopolymer, is known for its exceptional ability to retain moisture and enhance skin elasticity. The formulation was developed using an oil-in-water (O/W) emulsion base containing suitable excipients such as emulsifiers, humectants, emollients, and preservatives. Different formulations were prepared and evaluated for physicochemical properties including pH, viscosity, spreadability, homogeneity, appearance, and stability. The optimized formulation demonstrated desirable texture, good spreadability, non-greasy feel, and effective absorption upon topical application. Stability studies indicated no significant changes in color, odor, or consistency over the test period. Evaluation of the moisturizing efficacy revealed that the cream significantly improved skin hydration levels compared with the control. The study concludes that hyaluronic acid-based cream is a promising formulation for enhancing skin moisture retention and maintaining healthy, supple skin.