Septic arthritis, or joint infection, occurs when an infectious agent invades a joint, causing inflammation and potentially significant morbidity and mortality if left untreated. Causes include bacteria, viruses, fungi, and parasites. Physicians must rely on indirect signs and high suspicion; raised CRP, ESR, and weight-bearing difficulty enhance diagnosis. USG aids in quick joint screening and the detection of effusions. Lack of response to minimally invasive treatments necessitates an open approach. According to Ayurveda, it can be correlated with Kroshtukasheersha, which is responsible for Vata and Rakta Dusti. Aim of the study: To study the prevalence, aetiology, complications and management of septic arthritis through Ayurveda. Methods: Ayurveda Classical treatment was used to treat a 35-year-old female patient who complained of severe right knee joint pain along with swelling and locally rising temperature for 12 days. Results: After treatment, individual criteria were assessed by using subjective and objective parameters, and the patient showed encouraging results in this study. Conclusion: Acute Septic arthritis is still a major health problem in developing countries, including India. In Ayurveda, she was treated with the combination of Aushadies and classical Herbal preparations, which showed good efficacy, and no further accumulation of fluid was seen during follow-up.