This document describes a Compliance Framework for the GDI project. It gives an overview of the components of the Compliance Framework and explains how it facilitates continued improvements of the GDI processes, striving for excellence and building trust. Due to the broad heterogeneity across GDI nodes the path towards SOP compliance is broken down into individual steps to offer guidance and enable all nodes to engage with the Compliance Framework, regardless of the individual node’s level of maturity. Templates are provided to capture stafftraining records and to document a compliance assessment.