Wound healing is a dynamic and regulated physiological process that requires an appropriate environment to promote tissue regeneration and prevent microbial infection. Plant-derived bio actives have recently gained attention in hydrogel formulations due to their natural bioactive properties and antimicrobial properties. Among these, anthocyanins are of particular interest because of their potent antioxidant and anti-inflammatory activities, in addition to functioning as natural pH indicators that allow real-time monitoring of wound healing. This review highlights, anthocyanins extracted from Hibiscus sabdariffa were incorporated into a biocompatible hydrogel matrix and assessed for physicochemical characteristics, stability, and biological activities under in vitro conditions. Hydrogels are considered ideal candidates for wound healing applications due to their three-dimensional architecture, high water content, and similarity to the extracellular matrix, which together promote cell migration and tissue repair. Furthermore, wound sites typically exhibit pH variations, with regenerating tissues trending acidic and infected wounds more alkaline. This makes anthocyanin-loaded hydrogels multifunctional, as they not only support healing but also provide visible monitoring of wound status. Overall, the integration of Hibiscus sabdariffa-derived anthocyanins into polymeric hydrogels offers a promising, safe, and effective strategy for advanced wound care applications.