Abstract: Patient satisfaction in disease prevention and control reflects the quality of healthcare delivery, especially in developing countries like Rwanda. This study assessed factors influencing patient satisfaction among 220 outpatients at Muhima Referral Hospital using a cross-sectional design and structured questionnaires. Data were analyzed using SPSS version 26, with descriptive and chi-square tests applied. Results revealed that 69.8% of patients were satisfied with overall services, and 69.7% rated them as effective. Interpersonal relations were highly rated (80.7%), professionalism (84.8%), and communication clarity (81.7%). Accessibility (77%) and affordability (69.7%) also contributed to satisfaction, though 17.4% expressed dissatisfaction with access and 15.6% with waiting time. Significant predictors included waiting time (AOR = 2.94, p = 0.026), education level (p < 0.05), staff attitude (p = 0.004), and communication clarity. The study concludes that while satisfaction is high, improving affordability, access, and timeliness can further strengthen patient-centered care in Rwanda. Keywords: Accessibility of Services, Curative and Follow-up Services, Disease Prevention and Control, Health Security Factors, Patient Satisfaction, Personal Relationships and Staff Etiquette, Prevalence of Patient Satisfaction, Turnaround Time in Service Delivery. Title: Factors Associated with Patient Satisfaction in Disease Prevention Control among Patients Attending Outpatient Services at Muhima Referral Hospital-Rwanda, 2025 Author: Nizeyimana Fidele, Dr Amanuel Kidane Andegiorgish, Nduwamungu Alexis, Nsekeyimana Damien International Journal of Management and Commerce Innovations ISSN 2348-7585 (Online) Vol. 13, Issue 2, October 2025 - March 2026 Page No: 106-121 Research Publish Journals Website: www.researchpublish.com Published Date: 13-November-2025 DOI: https://doi.org/10.5281/zenodo.17599897 Paper Download Link (Source) https://www.researchpublish.com/papers/factors-associated-with-patient-satisfaction-in-disease-prevention-control-among-patients-attending-outpatient-services-at-muhima-referral-hospital-rwanda-2025