This paper proposes that fundamental limits in physics arise not from temporary technological gaps, but from inherently inaccessible scales of reality. Using a multi-scale perspective, it examines how phenomena at one level (e.g., quantum entanglement, Planck-scale gravity) depend on unobservable deeper or broader layers, creating an infinite regress/progression with no testable foundation. Drawing an analogy to Gödel’s incompleteness, the work argues that key unsolved problems—quantum gravity, dark energy, dark matter, and the unification of forces—may remain permanently beyond empirical resolution due to cross-scale feedback loops and observational barriers. Rather than pursuing a complete "Theory of Everything," science must accept epistemic boundaries and redirect effort toward pragmatically verifiable domains. This shift redefines the goals and philosophical scope of physical inquiry.