Abstract Background Male endocrine and reproductive disorders - including erectile dysfunction (ED), male infertility, benign prostatic hyperplasia (BPH), chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), prostate intraepithelial neoplasia (PIN), androgenic alopecia (AGA), and metabolic syndrome - share a unified pathological foundation: oxidative stress, nitric oxide (NO) deficiency, androgenic imbalance, mitochondrial dysfunction, and chronic low-grade inflammation. Conventional single-target pharmacotherapies often fail to restore systemic coherence across these axes. The present study introduces the Keyora Lycopene 23 in 1 formulation as a multi-axis nutritional intervention model designed to reconstruct the Redox–NO–Androgen–Mitochondrial network through integrated micronutrient synergy. Methods A systems nutrition approach was employed to analyze molecular coupling among redox, endothelial, and androgenic pathways. The formulation integrates 23 bioactive nutrients, with four functional clusters: l Antioxidant–Redox Axis Lycopene, vitamins C and E, selenium, and zinc modulate the Nrf2–NF-κB interface, neutralize ROS, and stabilize mitochondrial membrane potential. l Endothelial–NO Axis L-Arginine, magnesium, folate, and B-vitamins restore endothelial NO synthase (eNOS) coupling and improve vascular perfusion. l Endocrine–Androgen Axis Saw Palmetto, zinc, vitamin D₃, and lycopene regulate 5-α-reductase, rebalance testosterone/DHT dynamics, and suppress COX-2/TGF-β1 inflammatory cascades. l Mitochondrial Bioenergetic Axis Coenzyme Q10, B-complex vitamins, selenium, and polyunsaturated fatty acids (α-linolenic acid (ALA), linoleic acid (LA), oleic acid (OA)) activate PGC-1α–SIRT1–AMPK signaling, enhance ATP generation, and maintain cellular energy homeostasis. Results Cross-referenced evidence from clinical trials and mechanistic studies demonstrates that these integrated nutrients synergistically: l Reduce oxidative and inflammatory biomarkers (MDA, 8-OHdG, TNF-α, IL-6). l Improve sperm motility, concentration, and DNA integrity in male infertility. l Enhance endothelial NO-mediated vasodilation and erectile function in ED. l Normalize testosterone synthesis and reduce DHT-related prostatic proliferation in BPH and PIN. l Suppress androgenic inflammation and restore mitochondrial activity in AGA. l Improve lipid and glucose metabolism through mitochondrial biogenesis and antioxidant defense in metabolic syndrome. The combined action effectively decouples the Redox–NO–Androgen feedback loop, reinstating mitochondrial stability, vascular perfusion, and hormonal equilibrium. Conclusions The Keyora Lycopene 23 in 1 framework demonstrates that multi-nutrient systems engineering can restore metabolic and endocrine communication across redox, endothelial, and hormonal pathways. By targeting upstream molecular interdependence rather than downstream symptoms, this model establishes a new paradigm of nutritional systems pharmacology for men’s health - bridging reproductive, vascular, endocrine, and metabolic interventions through a single, mechanistically unified axis. Such integration provides a clinically translatable foundation for the prevention and rehabilitation of male endocrine and mitochondrial disorders.