Psoriasis is a chronic autoimmune skin disorder characterized by inflammation, scaling, and erythema. Turmeric (Curcuma longa) and Boswellia Serrata, with their potent anti-inflammatory and antioxidant properties, offer a promising approach to treating psoriasis. This review focuses on the development and preparation of a turmeric-Boswellia Serrata ethosomal cream, a novel topical formulation designed to enhance the delivery and efficacy of these herbal extracts. The ethosomal cream formulation combines the benefits of liposomes and ethanol, allowing for improved skin penetration and bioavailability of curcumin and boswellic acids. The synergistic action of these compounds may provide a multifaceted approach to managing psoriasis symptoms, including reducing inflammation, modulating immune responses, and promoting skin health. This review discusses the rationale, formulation, and potential benefits of turmeric-Boswellia Serrata ethosomal cream in the treatment of psoriasis, highlighting its potential as a natural, effective, and safe therapeutic option.