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Neurobehavioral Effects of High-Sugar Diet Assessed Using IntelliCage: Impairments in Learning, Memory, Cognitive Flexibility and Addiction-like Behavior in Mice

Authors: Siddiqui, Wajahath Mohammed; Bhasker, Nagilla; Rao Joginapally, Venkateshwara;

Neurobehavioral Effects of High-Sugar Diet Assessed Using IntelliCage: Impairments in Learning, Memory, Cognitive Flexibility and Addiction-like Behavior in Mice

Abstract

Excessive consumption of dietary sugar has been linked to metabolic and neurocognitive dysfunction, yet the behavioral consequences remain insufficiently characterized. Using the IntelliCage automated behavioral system, we investigated the long-term impact of a high-sugar diet (HSD) on learning, memory, cognitive flexibility, activity, and addiction-like behaviors in mice. Adult swiss albino mice were divided into control (standard chow) and HSD groups for 6 weeks. Behavioral tasks included place learning, reversal learning, activity monitoring, and sucrose preference. Mice on HSD exhibited deficits in acquisition and retention of memory tasks, impaired reversal learning indicative of reduced cognitive flexibility, altered locomotor activity, and enhanced sugar preference resembling addiction-like behavior. These findings suggest that chronic HSD consumption impairs cognitive performance in mice, with implications for understanding diet-related neurocognitive disorders in humans.

Keywords

Mice, Memory, High-sugar diet, Cognitive flexibility, Addiction-like behavior, IntelliCage

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green